发明名称 |
USE OF ANTIOXIDANTS AS AN ADJUVANT TO IMMUNE STIMULATORS TO AUGMENT TUMOR IMMUNITY AND PREVENT TOXICITY ASSOCIATED WITH OXIDATIVE STRESS |
摘要 |
The current application teaches methods and compositions useful for the treatment of cancer through administration of an antioxidant together with an immune stimulator at concentrations sufficient to augment antitumor immunity while simultaneously preventing inhibition of T cell function as a result of tumor secreted oxidative stress. Compositions such as toll like receptor agonists in combination with antioxidants are disclosed. In further embodiments, the application teaches the use of antioxidants to prevent immunotherapy associated oxidative stress, of which, one manifestation is vascular leak syndrome. In one specific embodiment, the application teaches the use of intravenous ascorbic acid as a means of reducing IL-2 associated toxicity. |
申请公布号 |
US2015342925(A1) |
申请公布日期 |
2015.12.03 |
申请号 |
US201514706238 |
申请日期 |
2015.05.07 |
申请人 |
BATU BIOLOGICS |
发明人 |
Wagner Samuel C.;KIM Andy J.;Theofilopoulos Dimitri N.;Dolan Brandon R.;Ajili Naseem |
分类号 |
A61K31/375;A61K47/36;A61K45/06;A61K38/20;A61K31/437 |
主分类号 |
A61K31/375 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating cancer through administration of an immune stimulant in combination with an antioxidant. |
地址 |
San Diego CA US |