发明名称 |
PYRROLOPYRIMIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES |
摘要 |
<p>The present invention relates to compounds or pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy. The invention particularly relates to compounds that are polo-like kinase (PLKs) inhibitors useful for the treatment of disease states mediated by PLK, especially PLK4, in particular such compounds that are useful in the treatment of pathological processes which involve an aberrant cellular proliferation, such as tumor growth, rheumatoid arthritis, restenosis and atherosclerosis.</p> |
申请公布号 |
EP2185562(B1) |
申请公布日期 |
2015.12.02 |
申请号 |
EP20080775359 |
申请日期 |
2008.07.25 |
申请人 |
JANSSEN PHARMACEUTICA, N.V. |
发明人 |
DIELS, GASTON STANISLAS MARCELLA;TEN HOLTE, PETER;FREYNE, EDDY JEAN EDGARD;GRAND-PERRET, THIERRY ANDRE REGIS;VAN EMELEN, KRISTOF;EMBRECHTS, WERNER CONSTANT JOHAN;BONNET, PASCAL GHISLAIN ANDRÉ |
分类号 |
C07D487/08;A61K31/529;A61P35/02;C07D498/08 |
主分类号 |
C07D487/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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