| 发明名称 | Conserved HBV and HCV sequences useful for gene silencing | ||
| 摘要 | Conserved consensus sequences from known hepatitis B virus strains and known hepatitis C virus strains, which are useful in inhibiting the expression of the viruses in mammalian cells, are provided. These sequences are useful to silence the genes of HBV and HCV, thereby providing therapeutic utility against HBV and HCV viral infection in humans. | ||
| 申请公布号 | US9200281(B2) | 申请公布日期 | 2015.12.01 |
| 申请号 | US201314043272 | 申请日期 | 2013.10.01 |
| 申请人 | Alnylam Pharmaceuticals, Inc. | 发明人 | Pachuk Catherine J;Satishchandran Chandrasekhar;Zurawski Vincent R.;Mintz Liat |
| 分类号 | C12N15/113;A61K48/00;A61K31/713 | 主分类号 | C12N15/113 |
| 代理机构 | Nixon Peabody LLP | 代理人 | Nixon Peabody LLP ;FitzGerald Mark J.;Resmick David S. |
| 主权项 | 1. A method for inhibiting expression of a polynucleotide sequence of hepatitis B virus in an in vivo mammalian cell comprising administering to said cell a double-stranded RNA effector molecule said double-stranded RNA effector molecule: (1) comprising: (a) a sequence selected from the group consisting of SEQ ID NO:57, SEQ ID NO: 56, and SEQ ID NO: 60; (b) the reverse complement of said selected sequence; wherein U is substituted for T; or (2) consisting of: (a) a sequence selected from SEQ ID NO: 54 or SEQ ID NO: 55, and (b) the reverse complement of said selected sequence; wherein U is substituted for T. | ||
| 地址 | Cambridge MA US | ||