胰高血糖素样肽第一型（ＧＬＰ－１）受体调控子及其于调节血糖浓度之用途;GLUCAGON-LIKE PEPTIDE 1 (GLP-1) RECEPTOR MODULATORS AND USES THEREOF IN REGULATING BLOOD GLUCOSE LEVELS

摘要

本发明系提供新颖的胰高血糖素样肽第一型(GLP-1)受体调控子，如式(I)或(II)之化合物，及其医药上可接受盐类。本发明亦提供涉及GLP-1受体调控子之医药组合物、套组、及用途，以经由如调控GLP-1受体媒介之内源性传讯途径而调节血糖浓度及/或治疗糖尿病。;The present disclosure provides novel glucagon-like peptide-1 (GLP-1) receptor modulators such as compounds of Formula (I) or (II), and pharmaceutically acceptable salts thereof. The present disclosure also provides pharmaceutical compositions, kits, and uses that involve the GLP-1 receptor modulators for regulating blood glucose levels and/or treating diabetes via, e.g., modulating the endogenous signaling pathways mediated by the GLP-1 receptor.