发明名称 |
Therapeutic viral microparticles for promoting stent biofunctionality and wound healing in vertebrate individuals |
摘要 |
The present disclosure provides viral microparticles comprising genetically-engineered baculoviruses (at least partially) embedded in a polymeric matrix for the local delivery of therapeutic nucleic acid molecules to the cells of a vertebrate individual (optionally in combination with a medical implant such as vascular stent platform). The viral microparticles are especially useful for promoting the healing of a wound as well as the repair of a blood vessel and prevent pathological scarring. Also provided herein are processes for making the viral microparticles, pharmaceutical compositions comprising viral microparticles as well as supports comprising the viral microparticles for the locating the viral microparticles in a wound or in the vicinity of a wound. |
申请公布号 |
AU2014252680(A1) |
申请公布日期 |
2015.11.26 |
申请号 |
AU20140252680 |
申请日期 |
2014.04.11 |
申请人 |
MANGOGEN PHARMA INC. |
发明人 |
PRAKASH, SATYA;PAUL, ARGHYA;SHUM-TIM, DOMINIQUE |
分类号 |
A61K35/76;A61K9/14;A61K31/7088;A61K38/18;A61K47/34;A61L31/08;A61L31/14;A61P17/02;C12N7/01;C12N11/08;C12N15/866 |
主分类号 |
A61K35/76 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|