HMGB1-BINDING BEADS AND USES THEREOF

摘要

Disclosed are therapeutic beads comprising agents, such as nucleic acids, that bind to high mobility group box 1 (HMGB1) and methods of treating subjects with conditions that would benefit from reducing the deleterious effects of HMGB1, such as inflammatory bowel diseases, comprising administering the beads to the gastrointestinal tract of the subjects.

主权项

1. A method of treating a subject with a disease or condition selected from the group consisting of an inflammatory cascade, an inflammatory bowel disease, Crohn's disease, colitis, ulcerative colitis, colitis-associated cancer and a condition that would benefit from reducing the deleterious effects of high-mobility group box 1 (HMGB1), the method comprising administering beads coated with one or more agents that bind to HMGB1 to the gastrointestinal tract of the subject in an amount effective to treat the disease or condition.