| 发明名称 |
VACCINE FOR INTRAUTERINE DISEASE |
| 摘要 |
Provided are compositions and methods for use in prophylaxis of puerperal metritis and improving reproductive function of ruminants. The methods and compositions are for subcutaneous administration and are provided as veterinary compositions and as articles of manufacture. The veterinary composition can contain whole cells selected from whole cells of Escherichia coli (E. coli), Trueperella pyogenes (T. pyogenes), Fusobacterium necrophorum (F. necrophorum) and combinations thereof; and/or proteins selected from F. necrophorum leukotoxin (LKT), E. coli type 1 fimbrial adhesin (FimH), T. pyogenes pyolysin (PLO), and all combinations of the whole cells and the proteins. |
| 申请公布号 |
US2015335725(A1) |
申请公布日期 |
2015.11.26 |
| 申请号 |
US201314647623 |
申请日期 |
2013.10.08 |
| 申请人 |
Cornell University |
发明人 |
BICALHO Rodrigo Carvalho;GILBERT Robert Owen;MACHADO Vinicius;BICALHO Marcela |
| 分类号 |
A61K39/114;A61K39/05;A61J1/18;A61K39/108 |
主分类号 |
A61K39/114 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for prophylaxis of puerperal metritis in a ruminant comprising subcutaneously administering a veterinary composition to the ruminant mammal, the veterinary composition comprising (1) whole cells selected from whole cells of Escherichia coli (E. coli), Trueperella pyogenes (T. pyogenes), Fusobacterium necrophorum (F. necrophorum) and combinations thereof; or (2) proteins selected from F. necrophorum leukotoxin (LKT), E. coli type 1 fimbrial adhesin (FimH), T. pyogenes pyolysin (PLO), and combinations thereof; or (3) a combination of (1) and (2). |
| 地址 |
Ithaca NY US |
