| 发明名称 |
USE OF SLURP1 AS AN IMUNOMODULATORY MOLECULE IN THE OCULAR SURFACE |
| 摘要 |
Methods for treating inflammation are disclosed, such as for treating ocular inflammation. In some embodiments, the ocular inflammation is inflammation of an ocular surface, such as keratitis. The methods include administering to a subject with inflammation a therapeutically effective amount of SLURP1, or a nucleic acid encoding SLURP1, thereby treating the inflammation. |
| 申请公布号 |
US2015335707(A1) |
申请公布日期 |
2015.11.26 |
| 申请号 |
US201514821567 |
申请日期 |
2015.08.07 |
| 申请人 |
University of Pittsburgh - Of the Commonwealth System of Higher Education |
发明人 |
Swamynathan Shivalingappa Kottur;Swamynathan Sudha;Buela Kristine-Ann Gallegos;Hendricks Robert Lee |
| 分类号 |
A61K38/17;A61K45/06 |
主分类号 |
A61K38/17 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method for treating ocular inflammation in a subject, comprising selecting a subject with ocular inflammation, and administering to the subject a therapeutically effective amount of a SLURP1 polypeptide, or a nucleic acid encoding the SLURP1 polypeptide, wherein the SLURP1 polypeptide comprises an amino acid sequence at least 95% identical to the amino acid sequence set forth as amino acids 23-103 of SEQ ID NO: 1, thereby treating the ocular inflammation subject. |
| 地址 |
Pittsburgh PA US |
