| 发明名称 | Methods for regulating neural differentiation | ||
| 摘要 | Methods of producing populations of predominantly astrocytes, neurons or oligodendrocytes are provided. In addition, methods of treating mammals having astroglial tumors, oligodendrocyte tumors, or neuronal tumors are provided. | ||
| 申请公布号 | US9193952(B2) | 申请公布日期 | 2015.11.24 |
| 申请号 | US201414153720 | 申请日期 | 2014.01.13 |
| 申请人 | The Regents of the University of Michigan | 发明人 | O'Shea Kathy Sue;Morell Maria;Tsan Yao-Chang |
| 分类号 | C12N5/079;C12Q1/68;C12N15/11 | 主分类号 | C12N5/079 |
| 代理机构 | Fish & Richardson P.C. | 代理人 | Fish & Richardson P.C. |
| 主权项 | 1. An in vitro method of producing a population of predominantly astrocytes comprising: overexpressing miRNA-410 in a population of neural stem cells or neuronal or glial precursor cells and, culturing said cells, wherein said overexpressing miRNA-410 and said culturing results in differentiation of said cells into a population of predominantly astrocytes, thereby producing a population of predominantly astrocytes. | ||
| 地址 | Ann Arbor MI US | ||