Chalcones as enhancer of antimicrobial agents

摘要

Compounds are described that are effective in enhancing the efficacy of antimicrobial agents. Also described are methods of using such compounds and compositions that include such compounds. The composition includes a chalcone compound and, optionally, an antimicrobial agent.

主权项

1. A composition comprising a carrier and as active ingredients
an antimicrobial agent selected from zinc citrate, triclosan, tetrahydrocannabinol, cetyl pyridinium chloride, magnolia, magnolol, honokiol and butyl magnolol, and one chalcone compound selected from the group consisting of 3-(4′-Hydroxy-3′-methoxy-phenyl)-1-(2′hydroxy-5′ methoxy-phenyl)-prop-2-ene-1-one, 3-(4′-Hydroxy-3′-methoxy-phenyl)-1phenyl-prop-2-ene-1-one, 3-(2″,3″-Dimethoxy-phenyl)-1-furan-2-yl-prop-2-ene-1-one, 3-(2″,5″-dimethoxy-phenyl)-1-(1H-pyrrol-2-yl)-prop-2-ene-1-one, and mixtures thereof.