| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: claimed invention relates to novel substituted quinolines of general formula(I), where Rstands for hydroxyCalkoxy and Ris H, Calkoxy or hydroxyCalkoxy; Ris H or F, Ris H, F, Cl, Br, I or CN; and X is CH or N, or to their stereoisomers, tautomers, or pharmaceutically acceptable salts. Invention also claims pharmaceutical compositions, which include such compounds and methods of applying compounds and compositions in treatment of hyper-proliferative disorders in mammals, especially humans.EFFECT: claimed compounds inhibit activity of protein- and tyrosinkinase and cell activity, such as proliferation, differentiation, apoptosis, migration and invasion.15 cl, 3 dwg, 2 tbl, 18 ex |
