Composition

摘要

Pharmaceutical compositions and methods for the treatment of neoplastic disease and comprising the combination of a taxane, such as docetaxel, with a CYP3A4 inhibitor, such as ritonavir. Methods of treatment of neoplastic disease incorporating the administration of a taxane and the administration of a CYP3A4 inhibitor, either simultaneously or separately, are also included. Further, kits for carrying out the methods are included. Solid pharmaceutical taxane compositions for oral administration comprising a substantially amorphous taxane, a carrier and a surfactant are also included.

主权项

1. A composition, which is:
(a) a solid pharmaceutical composition comprising a substantially amorphous taxane, a hydrophilic carrier, and a surfactant; (b) a pharmaceutical composition for oral administration, comprising a substantially amorphous taxane and a carrier wherein the substantially amorphous taxane is prepared by lyophilisation; or (c) a composition comprising a taxane and a CYP3A4 inhibitor together with one or more pharmaceutically acceptable excipients.