发明名称 |
KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF |
摘要 |
Certain compounds, or pharmaceutically acceptable salts or prodrugs thereof, are provided herein. Also provided are pharmaceutical compositions comprising at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. |
申请公布号 |
WO2015047982(A3) |
申请公布日期 |
2015.11.19 |
申请号 |
WO2014US56898 |
申请日期 |
2014.09.23 |
申请人 |
CHDI FOUNDATION, INC. |
发明人 |
DOMINGUEZ, CELIA;TOLEDO-SHERMAN, LETICIA, M.;PRIME, MICHAEL;MITCHELL, WILLIAM;WENT, NAOMI |
分类号 |
A61K31/381 |
主分类号 |
A61K31/381 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|