发明名称 |
PHARMACEUTICAL COMPOSITIONS AND METHODS FOR FABRICATION OF SOLID MASSES COMPRISING POLYPEPTIDES AND/OR PROTEINS |
摘要 |
Embodiments of the invention provide shaped masses comprising one or more drugs such as proteins or polypeptides and methods for forming such shaped masses. One embodiment provides a shaped mass comprising a drug such as a protein or polypeptide having a biological activity in the body of a mammal. The shaped mass is formed by compression of a precursor material comprising the drug wherein an amount of biologically active drug in the mass is a preserved above a minimum level. Drugs which may be incorporated into the shaped mass may include one or more glucose regulating proteins such as insulin, incretins; and immunoglobulins such as TNF-inhibiting antibodies or interleukin neutralizing antibodies. Embodiments of the shaped mass may be incorporated into a tissue penetrating member which is inserted into the intestinal wall allowing for the oral delivery of proteins and peptides which would otherwise be degraded in the intestinal tract. |
申请公布号 |
US2015329630(A1) |
申请公布日期 |
2015.11.19 |
申请号 |
US201514714120 |
申请日期 |
2015.05.15 |
申请人 |
InCube Labs, LLC |
发明人 |
Morales Mercedes;Imran Mir;Korupolu Radhika;Hashim Mir |
分类号 |
C07K16/24;A61K9/20 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
1. A shaped mass comprising a protein or polypeptide having a biological activity in the body of a mammal, the shaped mass formed by compression of a precursor material comprising the protein or polypeptide, wherein an amount of biologically active protein or polypeptide in the shaped mass is at least about 80% to that in the precursor material, the shaped mass having a density in a range of about 0.8 to about 1.10 mg/mm3. |
地址 |
San Jose CA US |