| 发明名称 | Drug-eluting catheter and method of manufacturing the same | ||
| 摘要 | Biocompatible nanoparticles 1 which entrap a bioactive substance and whose surface is positive-charge-modified are electrically adhered to a balloon portion 9 of a catheter main body 5 through a negatively charged resin layer 11, and thus a nanoparticle layer 12 is formed. After the catheter main body 5 is indwell in vivo, the nanoparticles 1 are gradually eluted from the nanoparticle layer 12 and are effectively delivered to cells. | ||
| 申请公布号 | US9186439(B2) | 申请公布日期 | 2015.11.17 |
| 申请号 | US200912921443 | 申请日期 | 2009.03.12 |
| 申请人 | AnGes MG, Inc.;Medikit Co., Ltd.;Hosokawa Micron Corporation | 发明人 | Morishita Ryuichi;Nakagami Hironori;Miyake Takashi;Mitamura Makoto;Nakajima Hiroaki;Matsuda Hiroaki;Suizu Nao;Kawano Yoshihumi;Takagi Kunihiko;Tsujimoto Hiroyuki;Tsukada Yusuke;Hara Kaori;Bando Yohei |
| 分类号 | A61L29/16;A61M25/10;B05D5/00;A61L29/08;A61M25/00 | 主分类号 | A61L29/16 |
| 代理机构 | Fish & Richardson P.C. | 代理人 | Fish & Richardson P.C. |
| 主权项 | 1. An expandable drug-eluting catheter, comprising: an expandable portion having a surface; a first coating on the surface of the expandable portion, the first coating comprising a negatively charged resin; and a second coating on the surface of the expandable portion, wherein the first coating is between the surface and the second coating, the second coating comprises a polymeric surface active agent and biocompatible nanoparticles, the biocompatible nanoparticles are formed in layers and in contact with each other, and the nanoparticles are positively charged and entrap a bioactive substance. | ||
| 地址 | Osaka JP | ||