| 发明名称 |
Human insulin analogues and derivatives comprising cysteine substitutions |
| 摘要 |
The present invention relates to human insulin analogues containing a substituting cysteine, to human insulin derivatives containing a PEGylated substituting cysteine and methods of making such. The compounds of the invention may be useful for the treatment of diabetes. |
| 申请公布号 |
US9187547(B2) |
申请公布日期 |
2015.11.17 |
| 申请号 |
US201214004532 |
申请日期 |
2012.03.15 |
| 申请人 |
Novo Nordisk A/S |
发明人 |
Vinther Tine Nygaard;Kjeldsen Thomas Boerglum;Hubalek Frantisek;Jensen Knud J. |
| 分类号 |
C07K14/62;A61K38/28;A61K38/00 |
主分类号 |
C07K14/62 |
| 代理机构 |
|
代理人 |
Bork Richard W. |
| 主权项 |
1. A human insulin analogue comprising a human insulin or a desB30 human insulin having one substitution wherein the substitution is a cysteine substitution selected from the group consisting of A10C, A14C, A15C, A18C, A19C, A21C, B25C, B27C. |
| 地址 |
Bagsvaerd DK |
