| 发明名称 |
Organic compounds |
| 摘要 |
The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed. |
| 申请公布号 |
US9187426(B2) |
申请公布日期 |
2015.11.17 |
| 申请号 |
US200913000413 |
申请日期 |
2009.06.25 |
| 申请人 |
Novartis AG;Xenon Pharmaceuticals |
发明人 |
Dales Natalie;Zhang Zaihui;Fu Jianmin;Hou Duanjie;Sun Shaoyi;Kodumuru Vishnumurthy;Pokrovskaia Natalia |
| 分类号 |
C07D401/14;A61K31/4439;C07D213/81;A61K31/444;C07D401/04;C07D409/12;C07D413/04;C07D413/14;C07D417/14 |
主分类号 |
C07D401/14 |
| 代理机构 |
|
代理人 |
Roth Joshua K. |
| 主权项 |
1. A compound selected from:
2-(3-(cyclopropylmethyl)-2-oxoimidazolidin-1-yl)-N-(pyridin-2-ylmethyl)isonicotinamide, 2-(3-(3,4-difluorobenzyl)-2-oxoimidazolidin-1-yl)-N-(pyridin-2-ylmethyl)-isonicotinamide, 2-(2-oxo-3-(4-(trifluoromethyl)benzyl)imidazolidin-1-yl)-N-(pyridin-2-ylmethyl)-isonicotinamide, and 2-(2-oxo-3-(4-(trifluoromethoxy)benzyl)imidazolidin-1-yl)-N-(pyridin-2-ylmethyl)-isonicotinamide, or a pharmaceutically acceptable salt thereof. |
| 地址 |
Basel CH |
