| 发明名称 |
CHIMERIC PCSK9 PROTEINS, CELLS COMPRISING SAME, AND ASSAYS USING SAME |
| 摘要 |
<p>A chimera protein comprising in the following order : a signal peptide, a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9) sequence consisting of amino acid residues at positions 35 to 696 of SEQ ID NO: 38, a transmembrane domain and a cytosolic domain, wherein said cytosolic (CT) domain comprises a sequence able to recycle the protein from the cellular membrane to endosomes.</p> |
| 申请公布号 |
CA2652247(C) |
申请公布日期 |
2015.11.17 |
| 申请号 |
CA20072652247 |
申请日期 |
2007.05.08 |
| 申请人 |
ADAERATA, LIMITED PARTNERSHIP |
发明人 |
SEIDAH, NABIL;DAVIGNON, JEAN;DUBUC, GENEVIEVE;BERNIER, LISE;TREMBLAY, MICHEL |
| 分类号 |
C12N9/64;C07K19/00;C12N5/10;C12N15/62;C12Q1/02;C12Q1/37;C12Q1/68;G01N33/48;G01N33/483 |
主分类号 |
C12N9/64 |
| 代理机构 |
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