发明名称 |
INHIBITORS OF FUSION BETWEEN VIRAL AND CELL MEMBRANES AS WELL AS COMPOSITIONS AND METHODS OF USING THEM |
摘要 |
The present application relates to an inhibitor of fusion between a viral membrane from an enveloped virus and a cell membrane, where the viral membrane comprises a fusion mediating protein including a C-terminal peptide. The inhibitor comprises the C-terminal peptide of the fusion mediating protein from an enveloped virus and tocopherol or a derivative or pharmaceutically acceptable salt thereof attached to the C-terminal peptide. Also disclosed is a pharmaceutical composition including the inhibitor as well as methods of inhibiting viral fusion, blocking viral spread, and preventing or treating viral infection, with the inhibitor or pharmaceutical composition. |
申请公布号 |
WO2015171924(A2) |
申请公布日期 |
2015.11.12 |
申请号 |
WO2015US29738 |
申请日期 |
2015.05.07 |
申请人 |
CORNELL UNIVERSITY;INSERM |
发明人 |
POROTTO, MATTEO;MOSCONA, ANNE;HORVAT, BRANKA;MATHIEU, CYRILLE |
分类号 |
A61K38/16;A61K31/355 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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