DIPEPTIDE ANALOGS FOR TREATING CONDITIONS ASSOCIATED WITH AMYLOID FIBRIL FORMATION

摘要

Dipeptide analogs comprising a tryptophan (Trp) moiety coupled to a beta-sheet breaker moiety derived from alpha-aminoisobutyric acid (Aib) are disclosed. The dipeptide analogs exhibit an improved performance in inhibiting amyloid fibril formation, as compared to previously described dipeptides. Compositions containing the dipetide analogs and uses thereof in treating amyloid-associated diseases and disorders are also disclosed.

主权项

1. A dipeptide analog comprising a tryptophan (Trp) moiety coupled to a beta-sheet breaker moiety, with the proviso that either said Trp moiety is not Trp or said beta-sheet breaker moiety is not α-aminoisobutyric acid (Aib) or an ester thereof.