| 发明名称 |
TOLEROGENIC SYNTHETIC NANOCARRIERS TO REDUCE ANTIBODY RESPONSES |
| 摘要 |
Disclosed are synthetic nanocarrier compositions, and related methods, comprising MHC Class II-restricted epitopes and immunosuppressants that provide tolerogenic immune responses, such as a reduction in CD4+T cell help specific to an antigen. |
| 申请公布号 |
US2015320728(A1) |
申请公布日期 |
2015.11.12 |
| 申请号 |
US201514810442 |
申请日期 |
2015.07.27 |
| 申请人 |
Selecta Biosciences, Inc. |
发明人 |
Fraser Christopher;Kishimoto Takashi Kei;Maldonado Roberto A. |
| 分类号 |
A61K31/436;A61K39/00;A61K47/48 |
主分类号 |
A61K31/436 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition comprising:
(i) a first population of synthetic nanocarriers that are coupled to immunosuppressants, and (ii) MHC Class II-restricted epitopes of an antigen that generates an undesired humoral immune response. |
| 地址 |
Watertown MA US |
