发明名称 |
Pharmaceutical composition for treatment and/or prophylaxis of cancer |
摘要 |
It is intended to identify a cancer antigenic protein specifically expressed on the surface of cancer cells and to provide an antibody targeting the antigenic protein and use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody comprising a heavy chain variable region comprising amino acid sequences of SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences of SEQ ID NOs: 9, 10, and 11, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising this antibody or fragment as an active ingredient. |
申请公布号 |
US9180188(B2) |
申请公布日期 |
2015.11.10 |
申请号 |
US201214236795 |
申请日期 |
2012.08.03 |
申请人 |
TORAY INDUSTRIES, INC. |
发明人 |
Kobayashi Shinichi;Okano Fumiyoshi;Minamida Yoshitaka;Saito Takanori |
分类号 |
C07K16/30;A61K39/395;A61K45/06;C07K16/28;A61K39/00 |
主分类号 |
C07K16/30 |
代理机构 |
Birch, Stewart, Kolasch & Birch, LLP |
代理人 |
Birch, Stewart, Kolasch & Birch, LLP |
主权项 |
1. An antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody or the fragment thereof comprising a heavy chain variable region comprising complementarity determining regions of SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising complementarity determining regions of SEQ ID NOs: 9, 10, and 11. |
地址 |
Tokyo JP |