发明名称 |
COMPOSITIONS AND METHODS OF CHIMERIC AUTOANTIBODY RECEPTOR T CELLS |
摘要 |
The invention includes compositions comprising at least one chimeric autoantibody receptor (CAAR) specific for an autoantibody, vectors comprising the same, compositions comprising CAAR vectors packaged in viral particles, and recombinant T cells comprising the CAAR. The invention also includes methods of making a genetically modified T cell expressing a CAAR (CAART) wherein the expressed CAAR comprises a desmoglein extracellular domain. |
申请公布号 |
WO2015168613(A2) |
申请公布日期 |
2015.11.05 |
申请号 |
WO2015US28872 |
申请日期 |
2015.05.01 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
PAYNE, AIMEE S.;ELLEBRECHT, CHRISTOPH T.;BHOJ, VIJAY;MILONE, MICHAEL C. |
分类号 |
A61K48/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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