METHODS FOR MODULATING EXPRESSION OF REV-ERB ALPHA IN BROWN ADIPOSE TISSUE

摘要

The methods and compositions described herein are useful for modulating expression of REV-ERBα and treating conditions associated therewith. In one embodiment, a method of affecting the cold tolerance, and thus, ability of a mammalian subject to survive extreme temperature changes is provided, comprising modulating the expression of REV-ERBα. In one embodiment, an antagonist of REV-ERBα is utilized.