| 摘要 |
PROBLEM TO BE SOLVED: To provide improved vaccines and methods for preventing and treating human papillomavirus (HPV) infection.SOLUTION: The present invention provides proteins comprising a consensus HPV Type 18 (HPV 18) E6 and E7 amino acid sequence, and nucleic acid molecules comprising nucleotide sequences encoding such proteins. These nucleic acid constructs and proteins encoded thereby provide improved immunogenic targets against which an anti-HPV immune response can be generated. Constructs which encode such proteins, vaccines which comprise such proteins, vaccines which comprise nucleic acid molecules that encode such proteins, and methods of inducing anti-HPV immune responses are also provided. |
