发明名称 |
HSP70 BINDING COMPOUND, USE, ANTITUMOUR PHARMACEUTICAL COMPOSITION, GENE CONSTRUCT FOR EXPRESSING AN HSP70 BINDER, PRODUCTION PROCESS, PROCESS FOR EVALUATING TUMOUR CELLS, METHOD OF SENSITIZATION OF TUMOUR CELLS TO CHEMOTHERAPEUTIC DRUGS |
摘要 |
The present invention provides the use of HspBP1 protein or part thereof for the preparation of an anti-tumor pharmaceutical composition, and its optional combination with one or more chemotherapeutic agents. Also disclosed are: a gene construct for the expression of said binder; a production process; a process of evaluation of tumor cells; and a method of sensitization of tumors to chemotherapeutic agents. The invention also provides a new experimental model in vivo and in vitro for the development/evaluation of anti-tumor agents. The pharmaceutical compositions of the invention provide anti-tumor action and have high specificity to neoplastic cells, resulting in less cytotoxicity to normal dividing cells. These and other advantages of the invention are characterized as a solution to the drawbacks of currently known chemotherapy therapeutic regimens. |
申请公布号 |
EP2940040(A1) |
申请公布日期 |
2015.11.04 |
申请号 |
EP20130867908 |
申请日期 |
2013.12.27 |
申请人 |
UNIÃO BRASILEIRA DE EDUCAÇAO E ASSISTÊNCIA- MANTENEDORA DA PUCRS |
发明人 |
CAZABUENA BONORINO, CRISTINA BEATRIZ;DUARTE DE SOUZA, ANA PAULA |
分类号 |
C07K14/47;A61K33/24;A61K33/40;A61K38/17;A61K45/06;A61K48/00;A61P35/00 |
主分类号 |
C07K14/47 |
代理机构 |
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地址 |
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