发明名称 |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF BRAIN CANCERS |
摘要 |
Described herein is an isolated viral particle having a genome that includes open reading frames that encode: Maraba proteins N, P, and L, or variants thereof; as well as Maraba protein M or protein delta 51M, or variants thereof; and a Bahia Grande G protein, a LCMV G protein, or an Ebola G protein. Maraba protein N may have a sequence which includes SEQ ID NO: 1. Maraba protein P may have a sequence which includes SEQ ID NO: 2. Maraba protein L may have a sequence which includes SEQ ID NO: 3. Maraba proteins M and delta 1M may have sequence which include SEQ ID NO: 4 and 5, respectively. Bahia Grande G protein may have a sequence which includes SEQ ID NO: 6. LCMV G protein may have a sequence which includes SEQ ID NO: 7. Ebola G protein may have a sequence which includes SEQ ID NO: 8. |
申请公布号 |
US2015307559(A1) |
申请公布日期 |
2015.10.29 |
申请号 |
US201214651761 |
申请日期 |
2012.12.12 |
申请人 |
CHILDREN'S HOSPITAL OF EASTERN ONTARIO RESEARCH INTITUTE INC. ;OTTAWA HOSPITAL RESEARCH INSTITUTE |
发明人 |
STOJDL David;BELL John Cameron |
分类号 |
C07K14/005;A61K35/766;C12N7/00 |
主分类号 |
C07K14/005 |
代理机构 |
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代理人 |
|
主权项 |
1. An isolated viral particle having a genome comprising open reading frames that encode:
a protein having a sequence comprising SEQ ID NO: 1, or a variant thereof; a protein having a sequence comprising SEQ ID NO: 2, or a variant thereof; a protein having a sequence comprising SEQ ID NO: 3, or a variant thereof; a protein having a sequence comprising SEQ ID NO: 4 or 5, or a variant thereof; and a protein having a sequence comprising SEQ ID NO: 6, 7 or 8. |
地址 |
Ottawa CA |