MODIFIED FVIII APITOPE PEPTIDES

摘要

The present invention provides peptides partly derivable from FVIII which are capable of binding to an MHC class II molecule without further antigen processing and being recognised by a factor VIII specific T cell. In particular, the present invention provides peptides comprising the sequence DNIMVTFRNQASRPY or PRCLTRYYSSFVNME with modifications at the N- and C-termini. The present invention also relates to the use of such a peptide for the prevention or suppression of inhibitor antibody formation in haemophilia A and/or acquired haemophilia.

主权项

1. A peptide comprising the FVIII-derived sequence DNIMVTFRNQASRPY which peptide (a) has the formulaXXGDNIMVTFRNQASRPYGXX wherein X is either Lysine or Glutamic acid; and (b) has one of the following sequences:(SEQ ID No. 17)KKGDNIMVTFRNQASRPYGKK (SEQ ID No. 18)KKGDNIMVTFRNQASRPYGKE (SEQ ID No. 19)KKGDNIMVTFRNQASRPYGEK (SEQ ID No. 25)KEGDNIMVTFRNQASRPYGKK (SEQ ID No. 26)KEGDNIMVTFRNQASRPYGKE (SEQ ID No. 27)KEGDNIMVTFRNQASRPYGEK (SEQ ID No. 29)EKGDNIMVTFRNQASRPYGKK (SEQ ID No. 30)EKGDNIMVTFRNQASRPYGKE and(SEQ ID No. 31)EKGDNIMVTFRNQASRPYGEK.