| 发明名称 | Neutralizing molecules to viral antigens | ||
| 摘要 | The present invention concerns methods and means for identifying, producing, and engineering neutralizing molecules against influenza A viruses, and to the neutralizing molecules produced. In particular, the invention concerns neutralizing molecules against various influenza A virus subtypes, including neutralizing antibodies against H5 and/or H3 and/or H1, such as, for example all of H1, H3, and H5 subtypes, and methods and means for making such molecules. | ||
| 申请公布号 | US9169318(B2) | 申请公布日期 | 2015.10.27 |
| 申请号 | US201113185386 | 申请日期 | 2011.07.18 |
| 申请人 | Sea Lane Biotechnologies, Inc. | 发明人 | Horowitz Lawrence;Bhatt Ramesh;Kashyap Arun |
| 分类号 | A61K39/145;A61P31/16;A61P37/04;A61K39/395;C07K16/10;A61K39/00 | 主分类号 | A61K39/145 |
| 代理机构 | Arnold & Porter LLP | 代理人 | Brasnjo Gabor;Arnold & Porter LLP |
| 主权项 | 1. A composition comprising an antibody, or an antigen binding fragment thereof, comprising a heavy chain polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:4, SEQ ID NO:9, SEQ ID NO:45 and SEQ ID NO:61, wherein the antibody: (i) neutralizes more than one subtype and/or more than one isolate of an influenza A virus, (ii) binds to a hemagglutinin (HA) stem polypeptide or fragment thereof that lacks an HA globular head polypeptide, and (iii) does not inhibit hemagglutination. | ||
| 地址 | Atherton CA US | ||