Collagen Fibrillar Construction

摘要

Methods and compositions are described for organizing collagen into fibrillar networks, e.g, short and long-range organization. Collagen produced by the disclosed methods can be used for tissue engineering.

主权项

1. A method of producing an organized array of collagen fibrils, the method comprising:
contacting a template with a still solution comprising collagen monomers in liquid crystalline phase; and neutralizing the solution in contact with the template, thereby inducing the assembly of the collagen monomers into an organized array of collagen fibrils.