DEUTERATED ALK INHIBITORS

摘要

This invention relates to novel ALK inhibitors of Formula I:;;as defined in the specification, and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering ALK inhibitors.

主权项

1. A compound of Formula I: or a pharmaceutically acceptable salt thereof,wherein
each Y1 is hydrogen or deuterium; each Y2 is hydrogen or deuterium; each Y3 is hydrogen or deuterium; each Y4 is hydrogen or deuterium; each Y5 is hydrogen or deuterium; each Y6 is hydrogen or deuterium; each Y7 is hydrogen or deuterium; each Y8 is hydrogen or deuterium; each Y9 is hydrogen or deuterium; each Y10 is hydrogen or deuterium; each Y11 is hydrogen or deuterium; each Y12 is hydrogen or deuterium; and Y13 is hydrogen or deuterium;provided that if each Y1, each Y2, each Y3, each Y5, each Y6, each Y7, each Y8, each Y9, each Y10, each Y11, each Y12 is hydrogen, and Y13 is hydrogen, then each Y4 is deuterium;and provided that if each Y9, each Y10, each Y11, and each Y12 is deuterium, then at least one additional Y is deuterium.