| 发明名称 |
CANCER-ASSOCIATED GERM-LINE AND SOMATIC MARKERS AND USES THEREOF |
| 摘要 |
The invention provides methods and compositions for identifying subjects, including canine subjects, having an elevated risk of developing cancer or having an undiagnosed cancer. These subjects are identified based on the presence of germ-line allele(s) and markers and various somatic mutations. |
| 申请公布号 |
US2015299795(A1) |
申请公布日期 |
2015.10.22 |
| 申请号 |
US201314404059 |
申请日期 |
2013.05.30 |
| 申请人 |
The Broad Institute, Inc. ;Trustees of Tufts College ;North Carolina State University ;Regents of the University of Minnesota |
发明人 |
Lindblad-Toh Kerstin;Tonomura Noriko;Mauceli Evan;Modiano Jaime;Breen Matthew |
| 分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method comprising
analyzing genomic DNA from a canine subject for the presence of a risk allele at a chromosome 5 marker that is BICF2G63035726 or BICF2G630183630, and identifying a canine subject having risk allele at a chromosome 5 marker that is BICF2G63035726 or BICF2G630183630 as a subject (a) at elevated risk of developing a hematological cancer or (b) having an undiagnosed hematological cancer. |
| 地址 |
Cambridge MA US |
