发明名称 |
HUMANIZED ANTI-TF-ANTIGEN ANTIBODIES |
摘要 |
Provided are humanized monoclonal antibodies (mAbs) or fragments thereof that bind with specificity to the Thomsen-Friedenreich (TF) human tumor antigen. Three distinct variable heavy and three variable light chains are provided, and can be combined to make a total of twenty-five distinct heavy and light chain combinations. Methods of using the mAbs and fragments thereof for cancer therapy and diagnostic imaging are provided, as are methods for making the mAbs and fragments thereof. In vitro cell cultures that express the mAbs and fragments thereof, and kits are also provided. |
申请公布号 |
CA2943681(A1) |
申请公布日期 |
2015.10.22 |
申请号 |
CA20152943681 |
申请日期 |
2015.04.20 |
申请人 |
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK |
发明人 |
RITTENHOUSE-OLSON, KATE;ABDULLAH, JULIA;ENG, JING YING;KOURY, STEPHEN T. |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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地址 |
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