MODULATION OF RENIN-ANGIOTENSIN SYSTEM (RAS) RELATED DISEASES BY ANGIOTENSINOGEN

摘要

Disclosed herein are antisense compounds and methods for modulating AGT and modulating a RAS pathway related disease, disorder or condition in an individual in need thereof. RAS related diseases in an individual such as hypertension or organ damage can be treated, ameliorated or prevented with the administration of antisense compounds targeted to AGT.

主权项

1. A method for inhibiting AGT expression in an animal having or at risk of having a RAS pathway related disease, disorder and/or condition comprising;
(a) selecting the animal suffering from the RAS pathway related disease, disorder or condition, and (b) administering a compound targeting AGT to the animal, wherein the compound administered to the animal inhibits AGT expression in the animal having or at risk of having the RAS pathway related disease, disorder and/or condition.