发明名称 |
THIOL-FUNCTIONALISING REAGENTS AND THEIR USES |
摘要 |
Reagents and methods for functionalising polypeptides with moieties poly(alkylene glycol) molecules and glycan groups are disclosed that are based on a functionalising reagent which comprises a nitrogen containing heterocyclic aromatic ring having a vinyl substituent that is capable of reacting with one or more thiol groups that are naturally present, or have been introduced into, the polypeptide, for example by employing a thiol group of one or more cysteine residues. The functionalising reagent is covalently linked to a poly(alkylene glycol) molecule, such as a polyethylene glycol (PEG) molecule, or a glycan group so that the reaction between the vinyl group and the thiol group in the polypeptide covalently links the polypeptide to the poly(alkylene glycol) molecule and/or the glycan group. |
申请公布号 |
EP2373675(B1) |
申请公布日期 |
2015.10.21 |
申请号 |
EP20090795797 |
申请日期 |
2009.12.21 |
申请人 |
GLYTHERA LIMITED |
发明人 |
WATTS, ANDREW, GRAHAM;KANTNER, TERRENCE;MACKENZIE, AMANDA, BARBARA |
分类号 |
C07K1/13;A61K47/48 |
主分类号 |
C07K1/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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