Methods and systems for prolonged localization of drug delivery

摘要

An effective method for prolonging localization of therapeutics within the rat gastrointestinal tract of at least about 12 hours is provided. The method includes localization of therapeutic agents that are nanoparticulated or nanoencapsulated. Attractive forces between an orally administered magnetic dose and an external magnet were monitored and internal dose motion in real time using biplanar videofluoroscopy was visualized. Tissue elasticity was quantified as a measure of tissue health by combining data streams. The methods address safety, efficacy, and monitoring capacity of magnetically localized doses and show a platform for testing the benefits of localized drug delivery.

主权项

1. A method for formulating a magnetic drug delivery device for a therapeutic agent, the method comprising:
contacting magnetic microparticles to a polymer and the therapeutic agent to produce a magnetic therapeutic microparticle suspension; extruding the magnetic therapeutic microparticle suspension to produce magnetic therapeutic polymer particles; attaching the magnetic therapeutic polymer particles to a an internal magnet having a field strength less than about 4 Tesla; and encapsulating the magnetic therapeutic polymer particles attached to the internal magnet in a capsule, thereby formulating the magnetic drug delivery device having an internal magnet and the therapeutic agent.