发明名称 |
A NONINVASIVE METHOD FOR MEASURING HISTAMINE FROM SKIN AS AN OBJECTIVE MEASURMENT OF ITCH |
摘要 |
<p>A method for measuring of histamine in an epidermis comprising applying an adhesive article to an epithelium of a mammal; allowing for adherence of epithelial cells to the adhesive article; removing the adhesive article from the epithelium of the mammal; preparing the adhesive article using standard laboratory methods for extraction; extracting histamine from the epithelial cells adhered to said adhesive article; measuring histamine from the epithelial cells adhered to said adhesive article; determining the amount of histamine in the epithelial cells as compared to a baseline sample. Further, a method of objectively measuring the perception of itch in mammals and wherein there is a reduction in histamine from a baseline level which is directly proportional to a reduction in an itch perception.</p> |
申请公布号 |
PT2478376(E) |
申请公布日期 |
2015.10.15 |
申请号 |
PT20100755273T |
申请日期 |
2010.09.09 |
申请人 |
THE PROCTER AND GAMBLE COMPANY |
发明人 |
JAMES ROBERT SCHWARTZ;KATHLEEN MARIE KERR;THOMAS MASSEY BURT;ANGELA MARIE FIENO;ROHAN LALITH WIMALASENA;GINA MARIE FADAYEL |
分类号 |
G01N33/68;G01N1/28 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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