发明名称 |
PERIPHERAL KAPPA OPIOID RECEPTOR AGONISTS FOR PREVENTING, INHIBITING OR TREATING NAUSEA AND VOMITING |
摘要 |
A method for preventing, inhibiting or treating nausea and/or vomiting in a mammalian subject, the method comprising administering an effective amount of a peripherally-restricted kappa opioid receptor agonist to the subject. The nausea and/or vomiting can be associated with use of an opioid, such as morphine or fentanyl. The peripherally-restricted kappa opioid receptor agonist can be an L-amino acid-containing peptide, a D-amino acid-containing peptide, or a synthetic peptide amide, such as for instance, D-Phe-D-Phe-D-Leu-D-Lys-[ω(4-aminopiperidine-4-carboxylic acid)] -OH (CR845). |
申请公布号 |
WO2015065867(A3) |
申请公布日期 |
2015.10.15 |
申请号 |
WO2014US62320 |
申请日期 |
2014.10.27 |
申请人 |
CARA THERAPEUTICS, INC. |
发明人 |
CHALMERS, DEREK, T.;JONES, JAMES, B. |
分类号 |
A61K38/00;A61K38/06;A61K38/07 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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