| 发明名称 |
CATIONIC ANTIMICROBIAL PEPTIDES |
| 摘要 |
A method for treating an infection comprises administering a peptide in synergistic combination with an antibiotic, wherein the peptide comprises an amino acid sequence with a formula selected from the group consisting of:;Bn1-Z; (a);Bn1-Z-Bn2; and (b);Z-Bn1 (c)wherein B is a basic amino acid residue;n1 and n2 are 1 to 6; andZ is a sequence of from about 7 to about 24 amino acid residues, said sequence having an average hydrophobicity value of at least 0.3 on the Liu-Deber scale. |
| 申请公布号 |
US2015290278(A1) |
申请公布日期 |
2015.10.15 |
| 申请号 |
US201514687682 |
申请日期 |
2015.04.15 |
| 申请人 |
The Hospital for Sick Children |
发明人 |
Deber Charles M. |
| 分类号 |
A61K38/10;A61K31/407;A61K31/496;A61K31/7036 |
主分类号 |
A61K38/10 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating an infection, the method comprising administering a peptide in synergistic combination with an antibiotic, wherein the peptide comprises an amino acid sequence with a formula selected from the group consisting of:
Bn1-Z; (a) Bn1-Z-Bn2; and (b) Z-Bn1 (c) wherein B is a basic amino acid residue; n1 and n2 are 1 to 6; and Z is a sequence of from about 7 to about 24 amino acid residues, said sequence having an average hydrophobicity value of at least 0.3 on the Liu-Deber scale. |
| 地址 |
Toronto CA |
