MEANS AND METHODS FOR PRODUCING HIGH AFFINITY ANTIBODIES

摘要

PROBLEM TO BE SOLVED: To provide a method for producing and/or selecting high affinity antibodies.SOLUTION: The method comprises inducing, enhancing and/or maintaining expression of Bcl-6 in a B-cell, and inducing, enhancing and/or maintaining expression of an anti-apoptotic nucleic acid in the B-cell, thus generating an antibody producing plasmablast-like B-cell. The method further comprises modulating functional activity of AID in the B-cell.