THE PRODUCT INTENDED FOR FACILITATION OF BONE OSSIFICATION, THE METHOD OF ITS MANUFACTURE AND USE

摘要

The product for facilitation of bone ossification consists of the native composite of hydroxyapatite structure with collagen. The principle of this new solution lies in the fact that the collagen contained in the native bone composite is modified and at least partially devoid of the terminal antigenic telopeptides, which is a reaction product of enzymatic atelopeptidation. The method of manufacture of the product that facilitates bone ossification lies in the fact that proteolytic enzymes are applied on the purified bone mash and these enzymes catalyze hydrolysis of the terminal collagen telopeptides and so they modify collagen by means of atelopeptidation. The use of the product that facilitates ossification of bones may consist in its surgical implantation in the processes of controlled bone regeneration or for filling of bone cysts and smaller missing parts of bones or in the application of this product as a food supplement that supports ossification. ?