主权项 |
1. A method for inducing cytotoxicities in cancer cells associated with deregulation of the activity of histone deacetylases in a subject in need thereof, comprising:
administering to the subject in need thereof a compound of Formula X: or a pharmaceutically acceptable salt thereof in a therapeutically effective amount to induce cytotoxicities in the cancer cells associated with deregulation of the activity of histone deacetylases, (I) wherein: R1 is hydrogen, (C1-C6)alkyl, or (C3-C6)cycloalkyl; R2 is (C6-C18)aryl, (C6-C18)aryl(C1-C6)alkyl, (C3-C18)heteroaryl(C1-C6)alkyl, halo(C6-C18)aryl(C1-C6)alkyl, or (C1-C6)alkoxy(C6-C18)aryl(C1-C6)alkyl; R3 is N-hydroxyamino-oxo(C2-C6)alkenyl; R4 is hydrogen, halogen, N-hydroxyamino-oxo(C2-C6)alkenyl, or N-hydroxyaminocarbonyl(C6-C18)aryl(C1-C6)alkylene; R5 is hydrogen, halogen, N-hydroxyamino-oxo(C2-C6)alkenyl, N-hydroxyaminocarbonyl(C6-C18)aryl(C1-C6)alkylene, or amino(C6-C18)aryl-oxo(C2-C6)alkenyl; and R6 is hydrogen, N-hydroxyamino-oxo(C2-C6)alkenyl, N-hydroxyamino(C6-C18)aryl (C1-C6)alkylene, or N-hydroxyaminocarbonyl(C6-C18)aryl(C1-C6)alkylene; (II) or wherein: R1, R2, R5 and R6 are each as defined in (I) above; R3 is hydrogen or N-hydroxyamino-oxo(C2-C6)alkenyl; and R4 is N-hydroxyamino-oxo(C2-C6)alkenyl, or N-hydroxyaminocarbonyl(C6-C18)aryl(C1-C6)alkylene; (III) or wherein: R1, R2, R4 and R6 are each as defined in (I) above; R3 is as defined in (II) above; and R5 is N-hydroxyamino-oxo(C2-C6)alkenyl, N-hydroxyaminocarbonyl(C6-C18)aryl(C1-C6)alkylene, or amino(C6-C18)aryl-oxo(C2-C6)alkenyl; (IV) or wherein: R1, R2, R4, R5 are each as defined in (I) above; R3 is as defined in (II) above; and R6 is N-hydroxyamino-oxo(C2-C6)alkenyl, N-hydroxyamino(C6-C18)aryl (C1-C6)alkylene, or N-hydroxyaminocarbonyl(C6-C18)aryl(C1-C6)alkylene. |