发明名称 |
METHOD OF ESTABLISHING ISOGENIC MULTI-XENOGRAFT MODEL AND THE USE THEREOF |
摘要 |
The present invention provides an immuno-deficient animal useful as an animal model for a human disease associated with a first mutation of a target gene, wherein the animal comprises (a) a first human xenograft comprising the target gene comprising the first mutation; (b) a second human xenograft comprising the target gene but lacking the first mutation, wherein the first human xenograft and second human xenograft are isogenic. Also provided here are methods of producing the animal model and methods of using such animal model. |
申请公布号 |
US2015282459(A1) |
申请公布日期 |
2015.10.08 |
申请号 |
US201514679924 |
申请日期 |
2015.04.06 |
申请人 |
Crown Bioscience Inc. (Taicang) |
发明人 |
Shi Qian;Sun Yanmei |
分类号 |
A01K67/027;A61K49/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
1. An immuno-deficient animal useful as an animal model for a human disease comprising (a) a first human xenograft comprising a target gene with a first mutation; (b) a second human xenograft comprising the target gene without the first mutation, wherein the first human xenograft and second human xenograft are isogenic. |
地址 |
Taicang CN |