ANIMAL MODEL WITH HUMAN IMMUNE SYSTEM

摘要

The present disclosure provides an immuno-deficient animal useful as an animal model for a human disease, wherein the animal comprises: (a) functional human immune cells; and (b) a human xenograft comprising a pathogenic human cell or tissue, wherein the human immune cells and the human xenograft meet at least one of the following criteria: i) the human xenograft expresses a threshold level of a therapeutic target for the human disease; ii) the human immune cells match with the human xenograft for at least one human leukocyte antigen (HLA) marker; and iii) the human xenograft cells expresses a desired level of the matched HLA marker. Also provides is a method of producing the animal model and use of the animal models.

主权项

1. An animal model for a human disease, said animal model comprising an immuno-deficient animal comprising:
(a) functional human immune cells derived from a first human subject; and (b) a human xenograft derived from a second human subject, said human xenograft comprising a pathogenic human cell or tissue; wherein: i) the human xenograft expresses a threshold level of a therapeutic target for the human disease; and/or ii) the human immune cells match with the human xenograft for at least one human leukocyte antigen (HLA) marker; and/or iii) the human xenograft cells expresses a desired level of the matched HLA marker.