发明名称 |
MODIFIED SULFAMIDASE AND PRODUCTION THEREOF |
摘要 |
Disclosed herein are a modified sulfamidase, a composition comprising a modified sulfamidase, as well as methods for preparing a modified sulfamidase and therapeutic use of such a sulfamidase. In particular, the present disclosure relates to a modified sulfamidase comprising substantially no epitopes for glycan recognition receptors, thereby enabling transportation of said sulfamidase across the blood brain barrier of a mammal, wherein said sulfamidase has catalytic activity in the brain of said mammal. |
申请公布号 |
WO2015150490(A1) |
申请公布日期 |
2015.10.08 |
申请号 |
WO2015EP57256 |
申请日期 |
2015.04.01 |
申请人 |
SWEDISH ORPHAN BIOVITRUM AB (PUBL) |
发明人 |
BERGHARD, CHARLOTTA;NORDLING, ERIK;SVENSSON GELIUS, STEFAN;TJERNBERG, AGNETA |
分类号 |
C07K14/435 |
主分类号 |
C07K14/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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