Nanoparticle composition and methods to make and use the same

摘要

The present invention provides a novel nanoparticle drug delivery system generated from poly(ortho ester) polymers with sustained drug release capability and can be functionalized to allow for systemic delivery to various organ systems throughout the body. One important aspect of this invention is that the nanoparticle drug delivery system generated from poly(ortho ester) polymers encapsulate several types of drugs in poly(ortho ester) nanoparticles, including but not limited to lipophilic, hydrophilic small and large molecules and also hydrophilic and lipophilic dyes by adopting appropriate emulsion techniques. These poly(ortho ester) nanoparticles are biodegradable, biocompatible and controlled release drug delivery system with zero order kinetics, which can be used in various biomedical applications such as eye-related diseases, cancer, arthritis, etc.

主权项

1. A composition comprising: a plurality of blank, biodegradable poly(ortho ester) nanoparticles comprising poly(ortho ester) and a latent acid at a molar ratio of 95:5 poly(ortho ester):latent acid, and a therapeutically effective amount of a bioactive agent encapsulated in the nanoparticles,
wherein the nanoparticles have a polydispersity value of less than or equal to about 0.25, wherein the bioactive agent is selected from a hydrophilic molecule and a hydrophobic molecule, wherein the bioactive agent is released from the nanoparticles for at least 14 weeks with zero-order kinetics, and wherein the encapsulation efficiency of the hydrophilic molecule is at least about 20%.