发明名称 |
INHIBITION OF HIV INFECTION THROUGH CHEMOPROPHYALXIS |
摘要 |
A process is provided for protecting a primate host from a self-replicating infection by an immunodeficiency retrovirus. Protection is achieved by administering to the primate host a combination of a pharmaceutically effective amount of a nucleoside reverse transcriptase inhibitor and a pharmaceutically effective amount of a nucleotide reverse transcriptase inhibitor prior to exposure to the immunodeficiency retrovirus. The administration is effective if provided in a single dose within 24 hours of the exposure. A regime of regular daily doses is also effective in providing protection against an immunodeficiency retrovirus becoming self-replicating after infecting a primate host. A process for controlling retrovirus transmission within a population includes the administration to a subpopulation at high risk for contracting an immunodeficiency retroviral infection the detailed combination prior to sexual exposure to a source of immunodeficiency retrovirus so as to preclude the immunodeficiency retrovirus from becoming self-replicating in a member of the subpopulation. |
申请公布号 |
US2015272972(A1) |
申请公布日期 |
2015.10.01 |
申请号 |
US201514679887 |
申请日期 |
2015.04.06 |
申请人 |
THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Serv |
发明人 |
Heneine Walid;Folks Thomas M.;Janssen Robert;Otten Ronald A.;Garcia Lerma Jose Gerardo |
分类号 |
A61K31/683;A61K31/675;A61K31/513 |
主分类号 |
A61K31/683 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Bethesda MD US |