发明名称 |
POLYMORPHIC FORMS OF RIFAXIMIN, PROCESSES FOR THEIR PRODUCTION AND USE THEREOF IN MEDICINAL PREPARATIONS |
摘要 |
<p>Crystalline polymorphic forms of rifaximin (INN), referred to as rifaximin alpha and rifaximin beta, and a poorly crystalline form referred to as rifaximin gamma, useful in the production of medicaments containing rifaximin for the oral and topical use and obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and causing the crystallization of the product by addition of water at a fixed temperature and for a fixed period of time, followed by drying under controlled conditions until reaching a precise water content in the end product, are the object of the invention.</p> |
申请公布号 |
KR20070113327(A) |
申请公布日期 |
2007.11.28 |
申请号 |
KR20077026410 |
申请日期 |
2007.11.13 |
申请人 |
ALFA WASSERMANN S.P.A. |
发明人 |
VISCOMI GIUSEPPE C.;CAMPANA MANUELA;BRAGA DARIO;CONFORTINI DONATELLA;CANNATA VINCENZO;RIGHI PAOLO;ROSINI GOFFREDO |
分类号 |
A61K31/44;C07D498/22;A61K31/395;A61K31/4188;A61K31/4353;A61K31/437;A61P31/00;A61P31/04 |
主分类号 |
A61K31/44 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|