SUBSTITUTED AMINOALKYL- AND AMIDOALKYL-BENZOPYRAN DERIVATIVES

摘要

This invention is related to novel aminoalkyl- and amidoalkyl- b enzopyran derivatives of the following general formula (I) wherein: the group (a) is a substituent in position 6 or 7 wherein: R is amono- or bi-cyclic (C<SUB>6</SUB>-C<SUB>10</SUB>) aryl or a mono- or bi-cyclic (5-10) membered heteroaryl radical, said radicals rings being optionally substituted by one or two substituents selected from (C<SUB>1</SUB>-C<SUB>5</SUB>) straight or branched alkyl, (C<SUB>1</SUB>-C<SUB>5</SUB>) straight or branched alkoxy, hydroxy, halo and trifluoromethyl; m is zero or an integer from 1 to 3; n, p, R<SUB>1</SUB> and R<SUB>2</SUB> are as herein indicated and R<SUB>3</SUB> and R<SUB>4</SUB> are both hydrogen or taken together represent an oxygen atom, and the pharmaceutically acceptable salts thereof. The compounds that are active as selective and reversible MAO-B inhibitors in vitro