发明名称 |
NEW PROLINE DERIVATIVE, METHOD FOR PRODUCING THE SAME, AND METHOD FOR PRODUCING OPTICALLY ACTIVE SECONDARY ALCOHOL THEREFROM |
摘要 |
PROBLEM TO BE SOLVED: To provide a method for producing an optically active secondary alcohol compound industrially useful as an intermediate for pharmaceuticals, agricultural chemicals, or perfumes in a high optical purity by reducing an asymmetric ketone compound with inexpensive and easily handleble trichlorosilane. SOLUTION: An asymmetric ketone compound (e.g., acetophenone) is reduced with trichlorosilane in the presence of an optically active proline derivative (e.g., cis-N-formyl-α'-(2,4,6-triethyl)phenyl-L-proline) represented by formula (I) (wherein R<SP>1</SP>is a 6 to 12C aryl group). COPYRIGHT: (C)2006,JPO&NCIPI |
申请公布号 |
JP2006151856(A) |
申请公布日期 |
2006.06.15 |
申请号 |
JP20040343600 |
申请日期 |
2004.11.29 |
申请人 |
TOKUYAMA CORP;NAGASAKI UNIV |
发明人 |
MATSUMURA ISAHIRO;ONOMURA OSAMU;IWASAKI FUMIAKI |
分类号 |
C07D207/16;C07B41/02;C07B53/00;C07B61/00;C07C29/143;C07C33/20;C07C33/24;C07C67/31;C07C69/732;C07C69/767;C07C201/12;C07C205/19 |
主分类号 |
C07D207/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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